A standard mastectomy should not be the only recommended breast surgical treatment for non-metastatic inflammatory breast cancer: A large population-based study in the Surveillance,Epidemiology, and End Results database 18 |
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| Affiliation: | 1. Urologic Clinic, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona, Italy;2. Department of Pathology, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona, Italy;1. School of Psychology, The University of Sydney, NSW, Australia;2. Centre for Medical Psychology and Evidence-based Decision-making (CeMPED), The University of Sydney, NSW, Australia;3. Specialist Oncology Services, Norwest Private Hospital, NSW, Australia;4. Nepean Cancer Care Centre, Sydney West Cancer Network, NSW, Australia;1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas;2. Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas;3. Banner MD Anderson Cancer Center, Gilbert, Arizona;4. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York;5. Department of Surgical Oncology, Brigham and Women''s Faulkner Breast Center and Dana-Farber Cancer Institute, Boston, Massachusetts;6. Scripps MD Anderson Cancer Center, La Jolla, California;7. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas;8. Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas;1. Department of Surgery, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands;1. School of Psychology, University of Sydney, NSW, Australia;2. Department of Oncology, Auckland Hospital, Auckland, New Zealand;3. Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; and Sir Peter MacCallum Dept. of Oncology, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population and Global Health, and Department of Medicine, St Vincent''s Hospital, The University of Melbourne, Melbourne, VIC, Australia;4. Sydney Catalyst Cancer Translational Cancer Centre, University of Sydney, NSW, Australia;5. University of Western Australia, Perth, WA, Australia;6. Breast Cancer Network Australia (BCNA), Melbourne, VIC, Australia;7. Psycho-Oncology Co-operative Research Group (PoCoG), and the Centre for Medical Psychology and Evidence-based Decision-making (CeMPED), University of Sydney, NSW, Australia |
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| Abstract: | BackgroundStandard mastectomy has long been the recommended breast surgical treatment for non-metastatic inflammatory breast cancer (IBC). The objective of this population-based study was to evaluate the significance of various breast surgical treatments for this highly aggressive subtype.MethodsThe Surveillance, Epidemiology, and End Results program registry was searched to identify women with non-metastatic IBC receiving standard treatment including breast surgery, radiation therapy and chemotherapy diagnosed between 1998 and 2013. Comparisons of the proportions of various breast surgery procedures over the years were performed using Pearson's chi-square test. Breast cancer-specific survival (BCSS) and overall survival (OS) were estimated using the Kaplan-Meier product limit method and compared across groups using the log-rank statistic. Cox models were then fitted to compare the association between various breast surgical procedures and BCSS or OS after adjusting for patient and tumor characteristics.ResultsA total of 3374 cases were identified. Over the years, the proportion of contralateral prophylactic mastectomy (CPM), breast reconstruction and both were increasing. The proportion of implant-based reconstruction was also increasing with no difference in survival compared with other types of reconstruction. There was no statistically significant difference in BCSS or OS among various breast surgery treatments, such as breast conserving surgery, CPM, breast reconstruction and standard unilateral mastectomy.ConclusionsBreast surgery is of great significance to the clinical outcome of IBC. Standard mastectomy should not be the only recommended breast surgical treatment. |
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| Keywords: | Inflammatory breast cancer Mastectomy Breast conserving surgery Contralateral prophylactic mastectomy Breast reconstruction Breast cancer-specific survival Overall survival |
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