Cognitive impairments in patients with first episode psychosis: The relationship between neurophysiological and neuropsychological assessments |
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| Affiliation: | 1. Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany;2. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany;3. LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf, Germany;1. Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States;2. Department of Psychology, Humboldt University, Berlin, Germany;3. VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), La Jolla, CA, United States;4. Department of Psychiatry, Columbia University, New York, NY, United States;1. Boston Children''s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA;2. Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA;3. Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA;4. Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, USA;5. Harvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA;6. E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, Neuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, 1011 Veterans Memorial Parkway, East Providence, RI 02915, USA;7. Beth Israel Deaconess Medical Center, Division of Cognitive Neurology and Berenson-Allen Center, 330 Brookline Avenue, Boston, MA 02115, USA |
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| Abstract: | Cognitive deficits in schizophrenia have been widely reported. Neurophysiological and neuropsychological assessments have been conducted to study these impairments. Event-related potentials (ERPs) are relevant markers of cognitive deficits in schizophrenia, and reductions in specific ERP components have been found. The MATRICS Consensus Cognitive Battery (MCCB) was developed to obtain a consensus battery for the assessment of cognitive deficits in schizophrenia. Here, we aimed to study modulations of several ERP components in first episode psychosis (FEP). We also examined neuropsychological deficits using the MCCB, and correlations between ERP and MCCB impairments. Thirty-eight FEP patients were compared to thirty-eight healthy controls. The following ERP components were examined: P1, N1, MMN, P2, early-P3 and late-P3. We used an auditory three-stimulus oddball paradigm, with standard (60%), target (20%) and distractor (20%) stimuli. FEP patients showed significantly lower amplitudes of P2, early-P3 and late-P3 components. FEP patients also showed significant deficits in all the MCCB cognitive domains. Finally, correlational analyses found strong associations between amplitudes of P2, early-P3 and late-P3 components and MCCB tests for attention and speed of processing. These findings indicate that deficits in late auditory ERP components are present in FEP, whereas early components are preserved. These reductions in late ERP components were related to attentional deficits in FEP as assessed by MCCB. These findings indicate that MCCB is a valid battery for studying cognitive impairments in the initial stages of schizophrenia, and highlight the utility of converging neurophysiological and neuropsychological measures to examine attentional impairments in schizophrenia. |
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| Keywords: | First episode psychosis Event-related potentials MCCB Cognition |
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