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Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid |
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| Authors: | Isa Lindqvist Janet L. Cunningham Jan Mulder Amalia Feresiadou Elham Rostami Johan Virhammar Eva Kumlien |
| Affiliation: | 1. Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden Department of Neuroscience, Karolinska Institute, Stockholm, Sweden;2. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden;3. Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden;4. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Department of Medical Sciences, Neurosurgery, Uppsala University, Uppsala, Sweden |
| Abstract: | Background and purposeCOVID-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, are decsribed.MetodsAnalysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.ResultsAntibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.ConclusionOur results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID-19 associated myoclonus. |
| Keywords: | astrocytes autoantibodies COVID-19 indirect immunohistochemistry myoclonus treatment |