Health-related quality of life results from the phase III CheckMate 067 study |
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| Institution: | 1. Department of Dermatology, University of Essen, Essen, Germany;2. German Cancer Consortium, Heidelberg, Germany;3. Royal Marsden Hospital, London, UK;4. Memorial Sloan Kettering Cancer Center, New York, NY, USA;5. Dana-Farber Cancer Institute, Boston, MA, USA;6. Istituto Oncologico Veneto, Veneto, Italy;7. University of Colorado, Denver, CO, USA;8. Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland;9. Hospital de la Timone, Marseille, France;10. Texas Oncology-Baylor Cancer Center, Dallas, TX, USA;11. University of Michigan, Ann Arbor, MI, USA;12. The College of Medicine, Swansea University, Swansea, UK;13. Weill Cornell Medical College, New York, NY, USA;14. Cross Cancer Institute, Edmonton, Alberta, Canada;15. Istituto Europeo di Oncologia, Milan, Italy;p. University of Zurich, Zurich, Switzerland;q. Tasman Oncology Research, Brisbane, QLD, Australia;r. Adelphi Values, Boston, MA, USA;s. Bristol-Myers Squibb, Princeton, NJ, USA;t. Duke University Medical Center, Durham, NC, USA;u. Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia;v. Royal North Shore and Mater Hospitals, Sydney, NSW, Australia |
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| Abstract: | BackgroundNivolumab, a monoclonal antibody of immune checkpoint programmed death 1 on T cells (PD-1), combined with ipilimumab, an immune checkpoint cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor, as combination therapy on the one hand and nivolumab as monotherapy on the other, have both demonstrated improved efficacy compared with ipilimumab alone in the CheckMate 067 study. However, the combination resulted in a higher frequency of grade 3/4 adverse events (AEs), which could result in diminished health-related quality of life (HRQoL). Here we report analyses of HRQoL for patients with advanced melanoma in clinical trial CheckMate 067.Patients and methodsHRQoL was assessed at weeks 1 and 5 per 6-week cycle for the first 6 months, once every 6 weeks thereafter, and at two follow-up visits using the European Organization for Research and Treatment of Care Core Quality of Life Questionnaire and the EuroQoL Five Dimensions Questionnaire. In addition to the randomised population, patient subgroups, including BRAF mutation status, partial or complete response, treatment-related AEs of grade 3/4, and those who discontinued due to any reason and due to an AE, were investigated.ResultsNivolumab and ipilimumab combination and nivolumab alone both maintained HRQoL, and no clinically meaningful deterioration was observed over time compared with ipilimumab. In addition, similar results were observed across patient subgroups, and no clinically meaningful changes in HRQoL were observed during follow-up visits for patients who discontinued due to any cause.ConclusionThese results further support the clinical benefit of nivolumab monotherapy and nivolumab and ipilimumab combination therapy in patients with advanced melanoma. The finding that the difference in grade 3/4 AEs between the arms did not translate into clinically meaningful differences in the reported HRQoL may be relevant in the clinical setting.Study numberNCT01844505. |
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| Keywords: | Health-related quality of life Checkpoint inhibitors Advanced melanoma Nivolumab Ipilimumab |
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