Analysis of positron emission tomography hypometabolic patterns and neuropsychiatric symptoms in patients with dementia syndromes |
| |
| Authors: | Jinghuan Gan Zhihong Shi Chuantao Zuo Xiaobin Zhao Shuai Liu Yongjie Chen Nan Zhang Li Cai Ruixue Cui Lin Ai Yi-Hui Guan Yong Ji |
| |
| Institution: | 1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China;2. Department of Neurology, Tianjin Dementia Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China;3. PET Center, Huashan Hospital, Fudan University, Shanghai, China;4. Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;5. Department of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China;6. Department of Neurology, General Hospital of Tianjin Medical University, Tianjin, China;7. Department of PET-CT Diagnostics, Tianjin Medical University General Hospital, Tianjin, China;8. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China |
| |
| Abstract: | Aims To estimate the proportions of specific hypometabolic patterns and their association with neuropsychiatric symptoms (NPS) in patients with cognitive impairment (CI). Methods This multicenter study with 1037 consecutive patients was conducted from December 2012 to December 2019. 18F-FDG PET and clinical/demographic information, NPS assessments were recorded and analyzed to explore the associations between hypometabolic patterns and clinical features by correlation analysis and multivariable logistic regression models. Results Patients with clinical Alzheimer's disease (AD, 81.6%, 605/741) and dementia with Lewy bodies (67.9%, 19/28) mostly had AD-pattern hypometabolism, and 76/137 (55.5%) of patients with frontotemporal lobar degeneration showed frontal and anterior temporal pattern (FT-P) hypometabolism. Besides corticobasal degeneration, patients with behavioral variant frontotemporal dementia (36/58), semantic dementia (7/10), progressive non-fluent aphasia (6/9), frontotemporal lobar degeneration and amyotrophic lateral sclerosis (3/5), and progressive supranuclear palsy (21/37) also mostly showed FT-P hypometabolism. The proportion of FT-P hypometabolism was associated with the presence of hallucinations (R = 0.171, p = 0.04), anxiety (R = 0.182, p = 0.03), and appetite and eating abnormalities (R = 0.200, p = 0.01) in AD. Conclusion Specific hypometabolic patterns in FDG-PET are associated with NPS and beneficial for the early identification and management of NPS in patients with CI. |
| |
| Keywords: | cognitive impairment fluorodeoxyglucose positron emission tomography frontotemporal lobar degeneration hypometabolism neuropsychiatric symptom |
|
|
