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FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1 |
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| Authors: | Luciana Yamamoto de Almeida,Fernanda dos Santos Moreira,Guilherme Augusto Silva dos Santos,Florence Juana Maria Cuadra Zelaya,César Alexander Ortiz,Michelle Agostini,Flávia Sammartino Mariano,Débora Campanella Bastos,Ulisses Ribaldo Nicolau Daher,Luiz Paulo Kowalski,Ricardo D. Coletta,Edgard Graner |
| Affiliation: | 1. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil;2. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil Contribution: Formal analysis, Investigation, Methodology;3. School of Medicine, University of Ribeirão Preto (UNAERP), Ribeirão Preto, Brazil;4. Hematology Division, Department of Medical Images, Hematology, and Clinical Oncology, University of São Paulo at Ribeirão Preto Medical School, Ribeirão 5. Preto, Brazil;6. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil;7. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil Contribution: Formal analysis, Methodology;8. Department of Biosciences, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil;9. Department of Clinical Oncology, A. C. Camargo Cancer Center, São Paulo, Brazil Department of Clinical Oncology, Hospital Amaral Carvalho, São Paulo, Brazil Contribution: Conceptualization, Formal analysis, Writing - review & editing;10. Department of Otorhinolaryngology and Head and Neck Surgery, A. C. Camargo Cancer Center, São Paulo, Brazil |
| Abstract: | |
| Keywords: | 5-fluorouracil cisplatin fatty acid synthase oral squamous cell carcinoma orlistat paclitaxel |