Comparison between macroscopic and microscopic evaluation of tumour responsiveness using the subrenal capsule assay |
| |
| Affiliation: | 1. Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, 100034, People''s Republic of China;2. Renal Pathology Center, Peking University Institute of Nephrology, Beijing, 100034, People''s Republic of China;3. State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People''s Republic of China;4. Laboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing 100034, People''s Republic of China;5. Key Laboratory of Renal Disease, Ministry of Health of China, People''s Republic of China;6. Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, People''s Republic of China |
| |
| Abstract: | Using the subrenal capsule assay in normal mice, a histologic evaluation was made of 8 human primary ovarian tumours and 3 human colon, 2 lung and 5 ovarian carcinomas growing in serial passage in nude mice. The results of the evaluation indicated that there is a tumour- and drug-dependent correlation between the macroscopically and microscopically evaluated effects, with cyclophosphamide demonstrating excellent concordance but adriamycin and cisplatin both demonstrating consistently more tumour cell killing on histologic analysis than could be appreciated macroscopically. Leukocyte infiltration and fibrosis were greatly increased by the latter 2 drugs, leading to unrepresentative macroscopic measurements. Variable amounts of host cell infiltration can also be demonstrated in the untreated control when normal mice are used. The use of nude mice decreases the discrepancy between macroscopic and microscopic evaluation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
