The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies |
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| Authors: | Maryam Afraie Pardis Mohammadzedeh Mobin Azami Sorour Khateri Kamran Zamani Farhad Moradpour Yousef Moradi |
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| Affiliation: | 1. Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj Iran ; 2. Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj Iran ; 3. Department of Physical Medicine and Rehabilitation, Hamedan University of Medical Sciences, Hamedan Iran ; 4. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj Iran |
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| Abstract: | IntroductionThe aim of this review was to combine the results of published cohort studies to determine the exact association between chronic liver disorders, and the severe form of COVID‐19, and its associated complications.MethodsThis meta‐analysis employed a keyword search (COVID‐19 and chronic liver disorders) using PubMed (Medline), Scopus, Web of Sciences, and Embase (Elsevier). All articles related from January 2019 to May 2022 were reviewed. The STATA software was used for analysis.ResultsThe risk of death in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease (RR: 1.52; CI 95%: 1.46–1.57; I 2: 86.14%). Also, the risk of acute respiratory distress syndrome (ARDS) and hospitalization in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease ([RR: 1.65; CI 95%: 1.09–2.50; I 2: 0.00%] and [RR: 1.39; CI 95%: 1.23–1.58; I 2: 0.20%]). Also, the meta‐analysis showed cough, headache, myalgia, nausea, diarrhea, and fatigue were 1.37 (CI 95%: 1.20–1.55), 1.23 (CI 95%: 1.09–1.38), 1.25 (CI 95%: 1.04–1.50), 1.19 (CI 95%: 1.02–1.40), 1.89 (CI 95%: 1.30–2.75), 1.49 (CI 95%: 1.07–2.09), and 1.14 (CI 95%: 0.98–1.33), respectively, whereas the risk of all these symptoms was higher in COVID‐19 patients with chronic liver diseases than ones without chronic liver disorders.ConclusionThe mortality and complications due to COVID‐19 were significantly different between patients with the chronic liver disease and the general population. |
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| Keywords: | chronic liver disease, complications, COVID‐ 19, meta‐ analysis, mortality |
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