| 单次发作抑郁症过氧化脂质及谷胱甘肽过氧化物酶检测的意义 |
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| 引用本文： | 陈佐明 张建宏. 单次发作抑郁症过氧化脂质及谷胱甘肽过氧化物酶检测的意义[J]. 新乡医学院学报, 1995, 12(2): 153-155 |
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| 作者姓名： | 陈佐明 张建宏 |
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| 作者单位： | 河南新乡第二附属医院 |
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| 摘 要： | 目的了解抑郁症血清的过氧化脂质及谷胱甘肽过氧化酶水平，探讨其病因。方法测定３２例抑郁症过氧化脂质及谷胱甘肽过氧化酶水平与正常人（３３例）对照研究，并对抑郁症ＬＰＯ与ＨＡＭＤ分值进行相关性分析。结果抑郁症ＬＰＯ明显高于对照组（Ｐ＜０．０１），且ＬＰＯ水平与ＨＡＭＤ分值是正相关（ｒ＝０．６０，Ｐ＜０．０１）。结论ＬＰＯ过多可能是造成脑细胞脂质过氧化损害而致抑郁的原因之一。
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| 关 键 词： | 抑郁症；过氧化脂质；自由基 |
Significance of detection of lipid peroxide and glutathione peroxidase in patients with single episode depression |
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| CHEN Zuo-Ming, ZHANG Jian-Hong, ZHANG Xiu-Ming, FANGRun-Cheng, YU Yun-Hua, QI Jiu-Ying,. Significance of detection of lipid peroxide and glutathione peroxidase in patients with single episode depression[J]. Journal of Xinxiang Medical College, 1995, 12(2): 153-155 |
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| Authors: | CHEN Zuo-Ming ZHANG Jian-Hong ZHANG Xiu-Ming FANGRun-Cheng YU Yun-Hua QI Jiu-Ying |
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| Affiliation: | The First Affiliated Hospilal |
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| Abstract: | Objechve To research the significance ofChanges of Lipid peroxide (LPO) andglutathione peroridese (GPX) in patients withsingle episode depression.Methods The levels of LPO and GPX weredetected respectively in 32 cases of depression and33 normal persons. The correlation analysis between the levels of LPO and grading of HAMDwas taken.Results The levels of serum LPO weresignificantly higher in depressive patients thanthat of control group (P < 0.01 ), and were positive correlation with HAMD gradings(r=0.60025, P< 0.01).Conclusion The higher level of serum Lpomay be one of causes of cerebrocellular injery andresulting in depression in single episodedepression. |
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| Keywords: | depression lipid peroxide glutathione peroxidase free radica |
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