NIDDM患者脂代谢紊乱的初步探讨

目的探讨非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者脂代谢紊乱的特点及其与各种慢性并发症、血糖的关系。方法将１０１例ＮＩＤＤＭ患者分为无慢性并发症组（单纯组）和慢性并发症组（并发症组），每组病人根据血糖情况又分为血糖控制较好组和血糖控制较差组，并设立正常对照组。观察各组病人脂代谢等紊乱的特点。结果各糖尿病组患者普遍存在着脂代谢异常，且以并发症组最为显著，主要表现为血甘油三酯、总胆固醇、低密度脂蛋白胆固醇和载脂蛋白Ｂ１００的升高，高密度脂蛋白胆固醇和载脂蛋白Ａ１的降低。血糖的控制有助于各组病人脂代谢紊乱的改善。结论ＮＩＤＤＭ患者普遍存在着脂代谢紊乱，此与糖尿病各种慢性并发症、血糖控制程度密切相关。

^A preliminary study on the disorders of lipid metabolism in non-insulin-dependent diabetics

Objective To study the features of abnormal lipid metabolism in non-insulin-dependent diabetes mellitus (NIDDM) patients, and its relation with chronic complications and plasma glucose.Methods The 101 cases of NIDDM patients were divided into two groups: diabetic group without chronic complications and diabetic group with chronic complocations; According to blood sugar level, the patients in each group were subdivided into two subgroups: plasma glucose controlled well group and plasma glucose controlled badly group. A control group in 32 normal subjects was designed.The features of abnormal lipid metabolism in every group of patients were investigated.Results There were general disorders of lipid metabolism in all the groups of patients with diabetes mellitus, especially in the group with chronic complications. It is showed that the plasma triglyceride (TG), cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and apolipoprotein B100 (apoB100) were higher than that of control group, high density lipoprotein-cholesterol (HDL- C) and apoAI were lower than that of control group. The controlling blood sugar could improve the abnormal lipid metabolism.Conclusion There were general disorders of lipid metabolism in NIDDM patients, which appears to have a relationship with diabetic chronic complications and blood sugar.