苯甲醛类衍生物的抗癌药效学研究

目的研究苯甲醛类衍生物的抗癌作用。方法采用小鼠移植性肿瘤模型，就制备的半合成品和全合成品β－环糊精苯甲醛（β－ＣｙｃｌｏｄｅｘｔｒｉｎＢｅｎｚａｌｄｅｈｙｄｅ简称β－ＣＤＢＡ２和β－ＣＤＢＡ１）。口制剂抗癌药效学进行探讨。组间比较用方差分析、ｔ检验及Ｘ２检验统计学处理。结果半合成品，即以植物无花果提取物为原料制备的β－ＣＤＢＡ２有明显抗癌活性。对小鼠宫颈癌（Ｕ１４）抑瘤率为３７％。最适剂量为每次２１．９ｍｇ·ｋｇ－１（灌胃）；对（Ｓ－１８０）肉瘤腹水型和（ＥＡＣ）艾氏腹水癌表现有较小抑瘤作用。而全合成品即以化学试剂苯甲醛为原料合成的β－ＣＤＢＡ１无抗癌活性。结论半合成品无毒性，且有抗癌活性，该抗癌作用可能与半合成品的天然无花果植物原料中含有苯甲醛类小分子芳香化合物等抗癌活性物质有关。天然苯甲醛类衍生物是较好的抗癌辅助药。）

Pharmacodynamic of benzyaldehy derivantin antineoplastic effects

Objective The aim of this paper was to studythe antineoplastic effects of benzaldehyde derivative.Method The pharmacodynamics of oral doseforms of benzaldehyde derivant, including thesynthetic preparation from chemical cyclodextrinbenzaldehyde (β-CDBA1) and semisyntheticcyclodextrin benzaldehyde from naturalReceptaculum Fici Caricae (β-CDBA2), werestudied in mice transplanted tumors with cervicalcarcinoma V14, ascites S18o and EAS. Data ofgroups were treated statistically with analysis ofvariance, t and x2 test.Results It was shown that semisyntheticβ-CDBA2possessed obviously antitumoral effectsand its inhibitory rate for cervical carcinomaV14was 37% under 21.9mg. kg-1 perig (compared with control group, P<0. 001). Therewere little antineoplastic effects of β-CDBA2onascites S180 and EAC were obseaved. But, notantitumor activities was obseaved in β-CDBA1.Conclusion The semisynthetic β-CDBA2 hasobviously antineoplastic activity. This effect maybe relation to chemical composition containedmicromolecule aromatic compound from naturalReceptaculum Fici Caricae that possessingantitumer actiVity. It is possible thatβ-CDBA2from natural benzaldehyde derivant is abetter assistant drug for antineoplastic treatment.