| 异香豆素类化合物的合成研究 |
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| 引用本文： | 闫福林,郭兰青.异香豆素类化合物的合成研究[J].新乡医学院学报,1995,12(3):217-219. |
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| 作者姓名： | 闫福林 郭兰青 |
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| 作者单位： | 河南新乡基础医学部化学教研室 |
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| 摘 要： | 目的探讨异香豆素类化合物的合成方法及构效关系。方法将２，３－二甲氧基－６－羧基苯甲醛与Ｗｉｔｔｉｇ试剂反应，然后氧化、环合脱水，得到目标化合物。结果经过三步反应，合成出一种新化合物３－丙基－５，６－二甲氧基异香豆素。结论此合成方法简便，原料易得，为异香豆素化合物的合成提供了一个好方法。
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| 关 键 词： | 异香豆素 药物 化学 合成 |
Study about synthesis of the isocoumarins |
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| YAN Fu-Lin, SUN Xiang-De, GUO Lan-Qing, LIU Rong.Study about synthesis of the isocoumarins[J].Journal of Xinxiang Medical College,1995,12(3):217-219. |
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| Authors: | YAN Fu-Lin SUN Xiang-De GUO Lan-Qing LIU Rong |
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| Abstract: | Objective To research the synthesis method and structure-effect relativities of the isocoumarins.Method The compound of 2,3-dimethoxy-6-carboxybenzaldehyde was reacted with Wittig reagent, then oxidized, cyclized and dehydrated.A target compound was obtained.Results A new compound of 3-propyl-5,6-dimethoxyisocoumarin has been synthezed through three steps reactions.Conclusion This synthetic route is short and the material is easily obtained, and provided a good method for synthesis of isocoumarins. |
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| Keywords: | isocoumarin chemical synthesis drug |
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