nm23—H1基因在甲状腺乳头状癌的表达及临床意义

目的：探讨nm23-H1基因在甲状腺乳头状癌的表达及其与临床病理指标的关系。方法：采用免疫组化S－P法检测201例例甲状腺乳头状癌，30例甲状腺良性增生及30例正常甲状腺组织中nm23-H1的表达情况。结果：（1）nm23-H1在甲状腺乳头状癌的表达阳性率为62．7％，明显低于两对照组（P＜0．01或P＜0．05）。（2）在甲状腺乳头状 nm23-H1在Ⅰ型、Ⅱ型、Ⅲ型间及包膜内型、腺内型、腺外型间的表达均有显著性差异。（3）有淋巴结转移组nm23-H1的阳性率为54．5％，低于无淋巴结转移组（75．0％），其蛋白表达与颈淋巴结转移呈负相关。nm23-H1阴性表达的患者发生颈淋巴结转移的可能性大。结论：nm23-H1基因的表达与甲状腺乳状癌的发和发展、浸润和颈淋巴结转移关系密切，检测nm23-H1可作为预测甲状腺乳头状癌颈淋巴、转移肾的有价值的参考指标。

Expression of nm23-H1 in Papillary Carcinoma and Its Clinical Significance

To evaluate the expression of nm23-Hl in papillary carcinoma and its clinical significance. Methods: The expression of nm23-Hl were determined with immunohistochemical technique in biopsy specimen of papillary thyroid carcinoma (PTC)(n =201),benign thyroid proliferation(BTP)(n =30) and normal control (NC)(n =30). Results: 1. The positive rate of nm23-Hl in PTC was 62.7 % and significantly lower than that in BTP and NC( P<0.01orP<0.05).2. The positive rate of nm23-Hl in PTC with lymph node metastasis was significantly lower than that without lymph node metastasis. 3. The expression of nm23-Hl in PTC was negatively correlated with lymph node metastasis (P<0.01). The patients with nm23-Hl negative expression had the high possibility of neck lymph node metastasis. Conclusion: The expression of nm23-H1 is correlated with carcinogenesis, progression, infiltration and neck lymph node metastasis of PTC, and it can serve as an important indicator for predicting lymph node metastasis of PTC.