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Mycobacterium malmoense in the north-east of England
Authors:M J Connolly  J G Magee  D J Hendrick  P A Jenkins
Affiliation:1. Host Defence Unit, Department of Respiratory Medicine, Royal Brompton Hospital, Guy''s and St Thomas’ NHS Foundation Trust, London, UK;2. National Heart and Lung Institute, Imperial College London, London, UK;3. Department of Respiratory Medicine, Royal Liverpool University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK;4. Chester Medical School, University of Chester, Chester, UK;5. Pharmacy Department, St James''s University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, UK;6. Pharmacy Department, St Bartholomew''s Hospital, Barts Health NHS Trust, London, UK;7. Pharmacy Department, Western General Hospital, NHS Lothian, Edinburgh, UK;8. Department of Thoracic Medicine, Royal Papworth Hospital, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK;9. West of Scotland Adult Cystic Fibrosis Unit, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK;10. Tuberculosis Service, Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK;11. Tuberculosis Service, Raphael House, Essex Partnership University NHS Foundation Trust, Rochford, UK;12. NTM Patient Care UK;13. NTM Network UK, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK;14. Department of Respiratory Medicine, Forth Valley Royal Hospital, NHS Forth Valley, Larbert, UK;15. Department of Respiratory Medicine, St Mary''s Hospital, Imperial College Healthcare NHS Trust, London, UK;p. Department of Respiratory Medicine, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK;q. UCL Respiratory, Division of Medicine, University College London, London, UK;r. Department of Respiratory Medicine, Victoria Hospital, NHS Fife, Kirkcaldy, UK;s. School of Medicine, North Haugh, University of St Andrews, St Andrews, UK;1. Department of Environmental and Occupational Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan;2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan;3. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taipei, Taiwan;4. Department of Health and Welfare, College of City Management, University of Taipei, Taipei, Taiwan;5. College of Public Health, National Taiwan University, Taipei, Taiwan
Abstract:We report a 6 year experience (1979-1984) of isolating Mycobacterium malmoense in the north-east of England. Eleven subjects were involved of whom 10 had active infection--9 pulmonary, one cervical adenitis. The 11 new isolates represent 0.7% of all new mycobacterial isolates during this period and 10% of new non-tuberculous isolates. In all but 2 cases there was pre-existing pulmonary disease and/or a recognised predisposing factor to mycobacterial infection. The organisms were generally insensitive to isoniazid but sensitive to both rifampicin and ethionamide. The results of chemotherapy are described.
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