Cerebellar Pathways in Mouse Model of Purkinje Cell Degeneration Detected by High-Angular Resolution Diffusion Imaging Tractography |
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| Authors: | Yuri Kanamaru Jianxue Li Natalie Stewart Richard L. Sidman Emi Takahashi |
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| Affiliation: | 1.Department of Medicine,Chiba University School of Medicine,Chiba,Japan;2.Department of Neurology, Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,USA;3.Department of Behavioral Neuroscience,Northeastern University,Boston,USA;4.Division of Newborn Medicine, Department of Medicine, Boston Children’s Hospital,Harvard Medical School,Boston,USA;5.Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital,Harvard Medical School,Boston,USA;6.Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital,Harvard Medical School,Charlestown,USA |
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| Abstract: | Cerebellar MR imaging has several challenging aspects, due to the fine, repetitive layered structure of cortical folia with underlying axonal pathways. In this MR study, we imaged with high-angular resolution diffusion imaging (HARDI) abnormal cerebellar cortical structure (gray matter) and myelinated axonal pathways (white matter) of a mouse spontaneous mutation, Purkinje cell degeneration (pcd), in which almost all Purkinje neurons degenerate, mainly between postnatal days 20 and 35. Mouse brains at postnatal day 20 (P20) and at 8 months were scanned, and known or expected abnormalities, such as reduction of the white matter volume, disorganized pathways likely linked to parallel fibers, mossy fibers, and other fibers running from/to the cerebellar cortex were observed in mutant mice. Such abnormalities were detected at both an early and a fully advanced degeneration stage. These results suggest that our diffusion MR tractography is useful for early detection and tracking of neuropathology in the cerebellum. |
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