野八角果实中的一个新苯丙素糖苷(英文)

目的:研究野八角果实的化学成分及生物活性。方法:应用硅胶、反相及半制备HPLC色谱法对野八角果实的乙醇提取物进行分离纯化,并用MTT法对所分离化合物进行细胞毒活性测试。结果:分离鉴定了8个化合物,包括1个新的苯丙素糖苷2,4-dihydroxy-allylbenzene-2-O-β-D-glucopyranoside(1)和7个已知的倍半萜内酯oligandruminB(2),oligandruminD(3),anisatin(4),veranisatinD(5),pseudomajucin(6),1α-hydroxy-3-deoxy-pseudoanisatin(7),8α-hydroxy-10-deoxycyclomerri-llianolide(8)。结论:化合物1,2,3,58为首次从野八角果实中分离得到,所有化合物对非小细胞肺癌A549细胞株均无细胞毒活性。

A new phenylpropanoid glycoside from the fruits of lllicium simonsii

AIM： To study the constituents and bioactivity of lllicium simonsii. METHODS： The extracts of the fruits of lllicium simonsii were submitted to a combination of chromatographic materials, silica gel, ODS column chromatography and finally preparative HPLC to obtain eight compounds which were further evaluated for their cytotoxicity by MTT method. RESULTS： A new phenylpropanoid glycolside, 2, 4-dihydroxy-allylbenzene-2-O-fl-D-glucopyranoside （1）, together with seven characteristic sesquiterpene lactones, oligandrumin B （2）, oligandrumin D （3）, anisatin （4）, veranisatin D （5）, pseudomajucin （6）, la-hydroxy-3-deoxy-pseudoanisatin （7）, 8a-hydroxy-10-deoxycyclomerrillianolide （8） were isolated. CONCLUSION： Compound 1 is new. Compounds 1, 2, 3, 5--8 were isolated from this plant for the first time. None of the isolates showed inhibitory effects on the growth of non-small cell lung tumor cell line A549.