| 叶瓜参中的三个脑苷脂(英文) |
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| 引用本文： | 喇明平,邵俊杰,焦健,易杨华. 叶瓜参中的三个脑苷脂(英文)[J]. 中国天然药物, 2012, 0(2): 105-109 |
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| 作者姓名： | 喇明平 邵俊杰 焦健 易杨华 |
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| 作者单位： | 第二军医大学药学院海洋药物研究中心;大连海晏堂生物有限公司 |
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| 基金项目： | supported by International Science and Technology Cooperation Project of China (No.2010DFB30810)~~ |
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| 摘 要： | 目的:研究叶瓜参化学成分。方法:对叶瓜参的65%乙醇提取物中小极性部分进行行分离纯化,得到脑苷脂分子种3,对脑苷脂分子种3应用高效液相色谱进一步分离纯化,得到3个脑苷脂单体,CF-3-1(1)、CF-3-2(2)和CF-3-3(3)。结果:根据化合物的波谱数据和化学方法鉴定了其结构。结论:三个化合物为首次从叶瓜参中分离得到,首次得到化合物2和3的单体化合物。
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| 关 键 词： | 鞘糖脂 脑苷脂 海参 叶瓜参 |
Three cerebrosides from the sea cucumber Cucumaria frondosa |
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| LA Ming-Ping,SHAO Jun-Jie,JIAO Jian,YI Yang-Hua. Three cerebrosides from the sea cucumber Cucumaria frondosa[J]. Chinese JOurnal of Natural Medicines, 2012, 0(2): 105-109 |
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| Authors: | LA Ming-Ping SHAO Jun-Jie JIAO Jian YI Yang-Hua |
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| Affiliation: | 1* 1Research Center for Marine Drugs, Second Military Medical University, Shanghai 200433, China; 2Dalian Haiyantang Biology Co., Ltd., Dalian 116021, China |
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| Abstract: | AIM: To study the chemical constituents of the sea cucumber Cucumaria frondosa. METHOD: Three sphingos-ine-type glucocerebrosides, CF-3-1, CF-3-2 and CF-3-3 were isolated by means of high performance liquid chromatography (HPLC) from a cerebroside molecular species 3 which was obtained from the less polar fraction of the 65% EtOH extract of the sea cucumber Cucumaria frondosa Gunnerus. RESULT: The structures of these cerebrosides were determined on the basis of chemical and spectro-scopic evidences. CONCLUSION: Three compounds were isolated from the sea cucumber Cucumaria frondosa for the first time. CF-3-3 and CF-3-2 were obtained as pure compounds for the first time. |
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| Keywords: | Glycosphingolipids Cerebrosides Sea Cucumber Cucumaria frondosa |
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