200例子宫颈癌患者的HPV感染研究

目的:通过对200例子宫颈癌患者HPV感染及临床相关信息的分析,为宫颈癌的防治研究提供线索和依据。方法:收集200例子宫颈癌患者新鲜病灶组织,用HPV分型基因芯片检测系统对组织标本进行23种HPV亚型的分型检测。结果:HPV检出率94.00%,其中HPV 16阳性率69.68%;HPV 18阳性率16.49%;HPV 16+18为7.45%;HPV 45为1.59%;HPV 18+33、HPV 33、HPV 16+45、HPV 58各1.06%;HPV 73占0.53%。HPV阳性率在20~60岁以上之间划分的五个年龄段无差异(P=0.75);HPV阳性率在按地理位置划分的五个区域之间无差异(P=0.5);HPV阳性率在农民和无业者中明显高于干部(P<0.025)。结论:该组资料的HPV阳性率达94.00%,且均为高危型,而HPV 16是最主要的亚型。子宫颈癌与HPV关系密切,是不同年龄、不同区域、不同职业患者的共同致病因素

The study of HPV infection in cervical cancer of 200 cases

Objective:Through the analysis of HPV infection and clinical information in 200cervical cancer,to give the clue and foundation for prevention and treatment of cervical cancer.Methods:The fresh tissues of 200 patients in our province were collected,the HPVgenotyping chip system was be used to study 23 HPV subtypes.Results:HPV infection was 94.00%,among them,HPV16 was 69.68%;HPV18 was 16.49%;HPV16 18 was 7.45%;HPV45 was 1.59%;HPV18 33,33,16 45,58 was 1.06% respectively,HPV73 was 0.53%.HPV positive weren't difference among five age groups of 20~60(P=0.75);HPV weren't difference also among five areas according to geographical position.HPV infection was higher in peasant and unprofessional than cadre(P<0.025).Conclusion:HPV infection is very high in our data,and all are high-risk.HPV16 is the most major subtype.The relationship is close between HPV and cervical cancer,HPV is the common factor of causing cancer at varying age,geographical position,profession.