| 胎盘促肾上腺皮质激素释放激素在人类分娩中的作用 |
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| 引用本文： | 倪鑫,唐晓露,孙刚. 胎盘促肾上腺皮质激素释放激素在人类分娩中的作用[J]. 生殖与避孕, 2002, 22(2): 107-110,120 |
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| 作者姓名： | 倪鑫 唐晓露 孙刚 |
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| 作者单位： | 第二军医大学生理学教研室,上海,200433 |
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| 基金项目： | 国家自然科学基金 39870 30 0和 39970 2 85的资助 |
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| 摘 要： | 在妊娠中、晚期 ,人类胎盘组织能产生和分泌大量的促肾上腺皮质激素释放激素 (CRH)进入母体和胎儿循环中。母体血浆 CRH的水平随着孕周升高 ,分娩前达到高峰 ,且与孕周长短呈正相关。早产孕妇血浆 CRH水平在妊娠中期开始就明显升高 ,治疗有效者 ,血浆 CRH水平明显回落。CRH可通过对胎儿下丘脑 -垂体 -肾上腺轴的作用来促进胎盘其他分娩激素的分泌以及对子宫平滑肌的作用而诱导分娩的启动
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| 关 键 词： | 胎盘 促肾上腺皮质激素释放激素(CRH) 分娩 |
| 文章编号： | 0253-357(2002)02-0107-04 |
The Role of Placental Corticotropin-Releasing Hormone in Human Parturition |
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| NI Xin TANG Xiao-lu SUN Gang. The Role of Placental Corticotropin-Releasing Hormone in Human Parturition[J]. Reproduction and Contraception, 2002, 22(2): 107-110,120 |
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| Authors: | NI Xin TANG Xiao-lu SUN Gang |
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| Abstract: | During the second and the third trimester of human pregnancy, placental syncytiotrophoblasts produce and secrete large amounts of corticotripin-releasing hormone (CRH) into the maternal and fetal circulation. The CRH concentration in maternal plasma increases exponentially with advancing gestation and controls the length of human pregnancy. Maternal CRH level is elevated in preterm labor and reduced after treatments. Placental CRH triggers the parturition through activating fetal hypothalamic-pituitary-adrenal (HPA) axis, stimulating other hormone secretion and enhancing myometrial contractility. |
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| Keywords: | placent corticotropin-releasing hormone (CRH) parturition |
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