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| 磷酸化JNK在小鼠腹水型肝癌高、低淋巴道转移株中表达的研究 | |
| 引用本文： | 张宇虹,唐建武,王绍清,李玲,孙成荣,王波,王梅. 磷酸化JNK在小鼠腹水型肝癌高、低淋巴道转移株中表达的研究[J]. 中国实验诊断学, 2008, 12(11) |
| 作者姓名： | 张宇虹 唐建武 王绍清 李玲 孙成荣 王波 王梅 |
| 作者单位： | 1. 大连医科大学附属第二医院超声科,辽宁,大连,116027 2. 大连医科大学病理学教研室,辽宁,大连,116044 3. 大连医科大学附属第二医院实验中心,辽宁,大连,116027 |
| 基金项目： | 国家自然科学基金 |
| 摘 要： | 目的观察磷酸化JNK(p-JNK)在小鼠腹水型肝癌高、低淋巴道转移株(Hca-F、Hca-P)中的表达水平,分析其在这两个细胞株中表达的关系及意义,以进一步探讨JNK基因在肝癌淋巴道转移过程中的作用。方法以小鼠腹水型肝癌淋巴道高转移株(Hca-F)和低转移株(Hca-P)为研究对象,采用Western Blot检测p-JNK在Hca-F和Hca-P两细胞株的表达。结果p-JNK在Hca-F细胞株中的表达显著高于Hca-P,二者间差异有显著性(P<0.01)。结论p-JNK可能在促进肝癌淋巴道转移中发挥作用,本研究为进一步探讨其机制和功能奠定了基础。 |
| 关 键 词： | 肝癌 淋巴道转移 |
Study of Expression of p-JNK in Mouse Hepatocarcinoma Asdtes Cell Lines Hca-F(highly metastatic)and Hea-P(low metastatic) |
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| ZHANG Yu-hong,TANG Jian-wu,WANG Shao-qing,et al.. Study of Expression of p-JNK in Mouse Hepatocarcinoma Asdtes Cell Lines Hca-F(highly metastatic)and Hea-P(low metastatic)[J]. Chinese Journal of Laboratory Diagnosis, 2008, 12(11) | |
| Authors: | ZHANG Yu-hong TANG Jian-wu WANG Shao-qing et al. |
| Affiliation: | ZHANG Yu-hong1,TANG Jian-wu2,WANG Shao-qing2,et al. |
| Abstract: | Objective To observe the expression levels of p-JNK in mouse hepatocarcinoma ascites cell lines Hca-F(highly metastatic) and Hca-P(low metastatic) and analyze the relationship and importance of p-JNK expression in these two cell lines for further study of its function and mechanism in lymphatic metastasis of hepatocarcinoma.Methods The expression of p-JNK protein was detected in Hca-F and Hca-P tumor cells by Western Blot.Results The Optical density(OD) of p-JNK in Hca-F was significantly higher than that in Hca-P(P<0.01).Conclusion p-JNK may be play an important role in lymphatic metastasis of hepatocarcinoma and it provides a solid foundation for further studies. |
| Keywords: | p-JNK Western Blot |
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