| 视网膜母细胞瘤患者和双亲染色体不稳定性观察 |
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| 引用本文： | 彭惠民,郑燕林,汤鼎华.视网膜母细胞瘤患者和双亲染色体不稳定性观察[J].重庆医科大学学报,1989(4). |
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| 作者姓名： | 彭惠民 郑燕林 汤鼎华 |
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| 作者单位： | 重庆医科大学生物学教研室
(彭惠民)，重庆医科大学第一医院眼科
(郑燕林)，重庆医科大学第一医院眼科(汤鼎华) |
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| 摘 要： | 本文对15例视网膜母细胞瘤(RB)患者,24例患者双亲以及正常对照16人的姊妹染色单体交换(SCE)率、微核(MN)率的观察表明,患者自发、丝裂霉素C(MMC)诱发的SCE率和MN率均与对照有显著差异。本实验为RB患者存在体细胞染色体不稳定性提供了证据,同时讨论了染色体不稳定性与RB发生的关系
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| 关 键 词： | 视网膜母细胞瘤 染色体 姊妹染色单体交换 微核 |
THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS |
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| Peng Huimin et al.THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS[J].Journal of Chongqing Medical University,1989(4). |
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| Authors: | Peng Huimin |
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| Institution: | Department of Biology |
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| Abstract: | The frequencies of sister chromatid exchange (SCE) and micronucleus (MN) of peripheral blood lymphocytes were determined in 15 patients with RB, their 24 parents and 16 normal controls.The results showed that the spontaneous,MMC induced SCE and MN rates in patients were significantly higher than those in controls. Therefore, the results provided some positive evidence for chromosome instability in RB patients. The relationship between chromosome instability and the origin of RB was also discussed |
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| Keywords: | Retinoblastoma Chromosome Sister chromatid exchange Micronucleus |
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