Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma |
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Authors: | Minoru Suzuki Hiroki Tanaka Genro Kashino Shinichiro Masunaga Toshinori Mitsumoto Hiroshi Tsutsui Akira Maruhashi |
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Affiliation: | a Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan b Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan c Sumitomo Heavy Industries, Ltd., Tokyo, Japan |
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Abstract: | Background and purposeTo confirm the feasibility of accelerator-based BNCT (AB-BNCT) for treatment of multiple liver tumors and malignant pleural mesothelioma (MPM), we compared dose distribution and irradiation time between AB-BNCT and reactor-based BNCT (RB-BNCT).Material and methodsWe constructed treatment plans for AB-BNCT and RB-BNCT of four multiple liver tumors and six MPM. The neutron beam data on RB-BNCT were those from the research reactor at Kyoto University Research Reactor Institute (KURRI). The irradiation time and dose-volume histogram data were assessed for each BNCT system.ResultsIn BNCT for multiple liver tumors, when the 5 Gy-Eq dose was delivered as the mean dose to the healthy liver tissues, the mean dose delivered to the liver tumors by AB-BNCT and RB-BNCT was 68.1 and 65.1 Gy-Eq, respectively. In BNCT for MPM, when the mean lung dose to the normal ipsilateral lung was 5 Gy-Eq, the mean dose delivered to the MPM tumor by AB-BNCT and RB-BNCT was 20.2 and 19.9 Gy-Eq, respectively. Dose distribution analysis revealed that AB-BNCT is superior to RB-BNCT for treatment of deep-seated tumors.ConclusionsThe feasibility of the AB-BNCT system constructed at our institute was confirmed from a clinical viewpoint in BNCT for multiple liver tumors and MPM. |
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Keywords: | Accelerator-based neutron source Boron neutron capture therapy Liver tumor Malignant pleural mesothelioma |
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