血清和腹腔液CA125对子宫内膜异位症和子宫腺肌症的诊断价值

目的:探讨血清和腹腔液CA125对子宫内膜异位症(内异症)和子宫腺肌症的诊断价值。方法:采用化学免疫发光法测定40例子宫内膜异位症、23例子宫腺肌症和15例正常对照组患者血清和腹腔液的CA125水平。结果:子宫内膜异位症组和子宫腺肌症组的血清CA125均高于对照组(P<0.01),子宫腺肌症的阳性率高于内异症组(P<0.01);内异症组腹腔液CA125水平高于对照组(P<0.01);子宫腺肌症组腹腔液水平与对照组无显著性差异(P>0.05)。轻型内异症者血清CA125与对照组无显著性差异(P>0.05),而腹腔液CA125水平显著高于对照组(P<0.01);重型内异症组血清和腹腔液CA125均高于对照组(P<0.01)。结论:如用于子宫内膜异位症的辅助诊断,腹腔液CA125较血清CA125敏感;如用于子宫腺肌症的诊断,血清CA125较腹腔液CA125敏感。

Diagnostic value of CA125 in serum and peritoneal fluid for endometriosis and adenomyosis

Objective:To investigate the diagnostic value of CA125 in serum and peritoneal fluid(PF) for endometriosis(EM) and adenomyosis.Methods:CA125 in serum and PF were measured using the chemiluminescent enzyme immunometric assay in 40 EM,23 adenomyosis and 15 of control group.Results:Both the serum CA125 level of EM and adenomyosis were significant higher than that of control group(P<0.01).The positive rate of serum CA125 of adenomyosis was significant higher than that of EM(P<0.01).There was significant difference in the measurement of CA125 of PF between EM and control group(P<0.01),but showed no significant diffenence between adenomyosis and control group.There were no significant difference in the serum CA125 between mild EM and control group,but show significant difference in PF CA125.Of the severe EM patients,both the CA125 of serum and PF were significant higher than that of the control(P<0.01).Conclusion:PF CA125 is more sensitive than serum CA125 in diagnosis of EM,and less sensitive in diagnosis of adenomyosis.