A Clinicopathological Study of Adenocarcinoma in Situ of the Cervix. The Influence of Cervical HPV Infection and Other Factors, and the Role of Conservative Surgery |
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| Authors: | J. L. Nicklin MBBS Dip RACOG R. G. Wright BSc MB ChB FRCPA J. R. Bell MBBS FRCPath FRCPA H. Samaratunga MBBS LRCP MRCS FRCPA N. C. Cox BSc ADAC CT B. G. Ward MBBS PhD MRCOG FRACOG |
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| Affiliation: | Department of Obstetrics and Gynaecology, University of Queensland, Brisbane. |
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| Abstract: | Adenocarcinoma in situ (ACIS) of the uterine cervix is an increasingly recognized disease. Thirty-seven cases were reviewed to determine the effect of HPV, marital status, parity, smoking habit and age on the topography and behaviour of this lesion. Using a commercial probe, 25% of 28 lesions tested were positive for HPV 16/18. The presence of HPV and a history of smoking appeared to exert no significant influence upon the topography and behaviour of ACIS. Nulliparity and a history of never being married was associated with a significant reduction in the incidence of coexisting CIN lesions. Age less than 36 years was associated with a significant reduction in the proximal linear extent of ACIS. While hysterectomy is probably the definitive treatment for ACIS of the cervix, there is an important place for conservative management by conization alone. Patients younger than 36 years are most likely to be desirous of retained fertility and appear to have the lesions most amenable to conservative surgery. |
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