Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man |
| |
Authors: | Székely J. I. Török Katalin Karczag I. Tolna Judit Till Mária |
| |
Affiliation: | (1) Institute for Drug Research, POB 82, H-1325 Budapest, Hungary;(2) Department of Psychiatry, Semmelweis University Medical School, Balassa u. 6., H-1083 Budapest, Hungary |
| |
Abstract: | The effects ofd-Met2, Pro5-enkephalinamide (EA) on pain tolerance and some cognitive functions have been examined in healthy male volunteers. Dihydrocodeine (DC) was used as reference substance. Applying the submaximum effort tourniquet technique EA (10 mg SC) was found to elevate the pain threshold similarly to DC (20 mg SC). Neither DC nor EA impaired the performance in the symbol cancellation test, which quantitates the intensity of attention. In this assay rather a slight improvement was detected. In addition the short-term memory performance (Wechsler test) was also improved by EA and DC. No alteration was seen in the word fluency test, an indicator of long-term (semantic) memory. The data show that EA not only improves pain tolerance but some of its mental effects are similar to those of a classical morphine congener DC. |
| |
Keywords: | Opiates Opioid peptides Enkephalin analogue Pain threshold Pain tolerance Cognitive functions Memory Attention D-Met2, Pro5-enkephalinamide |
本文献已被 SpringerLink 等数据库收录! |
|