GABAergic circuitry in the dorsal division of the cat medial geniculate nucleus |
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Authors: | Coomes Diana L Bickford Martha E Schofield Brett R |
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Affiliation: | Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40202, USA. |
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Abstract: | Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the thalamus. We used postembedding immunocytochemistry to examine the synaptic organization of GABA-positive profiles in the dorsal superficial subdivision of the cat medial geniculate nucleus (MGN). Three groups of GABA-positive profiles participate in synapses: axon terminals, dendrites, and presynaptic dendrites. The presynaptic GABA-positive terminals target mainly GABA-negative dendrites. The GABA-positive postsynaptic profiles receive input primarily from GABA-negative axons. The results indicate that the synaptic organization of GABA-positive profiles in the dorsal superficial subdivision of the MGN nucleus is very similar to that in other thalamic nuclei. |
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Keywords: | auditory system thalamus inhibition neuroanatomy electron microscopy |
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