A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii |
| |
| Authors: | Hosoe Tomoo Fukushima Kazutaka Takizawa Kayoko Itabashi Takeshi Kawahara Nobuo Vidotto Valerio Kawai Ken-Ichi |
| |
| Affiliation: | Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. hosoe@hoshi.ac.jp |
| |
| Abstract: | In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
