| Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis |
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| 作者姓名： | Dan Chen Anmin Chen Fengjin Guo |
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| 作者单位： | [1]Department of orthopedics, Shengli Oil-field Central Hospital, Dongying 257034, Shandong province, China [2]Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China |
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| 摘 要： | Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.
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| 关 键 词： | 骨质疏松症 破骨细胞分化因子 髋骨折 OPGmRNA ODFmRNA 基因表达 |
| 修稿时间： | 2007-06-04 |
Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis |
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| Dan Chen,Anmin Chen,Fengjin Guo.Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis[J].Acta Universitatis Medicinalis Nanjing,2007,21(5):321-323. |
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| Authors: | Dan Chen Anmin Chen and Fengjin Guo |
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| Institution: | Department of orthopedics, Shengli Oil-field Central Hospital, Dongying 257034, Shandong province, China;Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China;Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China |
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| Abstract: | Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption. |
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| Keywords: | osteoporosis fracture osteoprotegerin osteoclast differentiation factor osteoporosis fracture patients essential inducing promoting bone resorption Aged signals gene expression high mRNA Results method Control Observer Group cases Methods tissue |
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