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Restriction of placental vasculature in a non-human primate: a unique model to study placental plasticity |
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| Authors: | Roberts V H J Räsänen J P Novy M J Frias A Louey S Morgan T K Thornburg K L Spindel E R Grigsby P L |
| Affiliation: | a Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center (ONPRC), Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA b Division of Neurosciences, Oregon National Primate Research Center (ONPRC), Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA c Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA d Heart Research Center, Oregon Health & Science University, Portland, OR, USA e Department of Medicine (Cardiovascular Medicine), Oregon Health & Science University, Portland, OR, USA f Department of Pathology, Oregon Health & Science University, Portland, OR, USA |
| Abstract: | The limits of placental plasticity, i.e., the ability of the placenta to adapt and alter its growth trajectory in response to altered fetal requirements, are not known. We report fetal and placental hemodynamic adaptations in a novel non-human primate model in which the fetal inter-placental bridging vessels were surgically ligated. Doppler ultrasound studies showed that the rhesus placenta compensates for an approximate 40% reduction in functional capacity by increased growth and maintenance of umbilical volume blood flow. This unique experimental animal model has applications for mechanistic studies of placental plasticity and the impact on fetal development. |
| Keywords: | Placental plasticity Non-human primate Fetal growth restriction Feto-placental blood flow Developmental programming |
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