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No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese |
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| Authors: | Yu Jin-Tai Sun Yan-Ping Ou Jiang-Rong Cui Wei-Zhen Zhang Wei Tan Lan |
| Institution: | a College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China b Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China c Department of Neurology, the Affiliated Hospital of the Medical College of Qingdao University, Qingdao, China d Department of Gerontology, Qingdao Mental Health Center, Qingdao, China |
| Abstract: | Toll-like receptor 2 (TLR2) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and is functionally involved in the microglia-mediated inflammatory response and amyloid β (Aβ) clearance. In the current study, 7 single nucleotide polymorphisms (SNPs) that span the TLR2 were selected and their associations with late-onset AD (LOAD) risk were assessed in a case-control sample comprising 785 individuals in a Han Chinese population. No significant differences in the frequency of TLR2 alleles, genotypes, and haplotypes in the AD cases were detected compared with the controls. TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population. |
| Keywords: | Alzheimer's disease TLR2 Polymorphism Association |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |