Epidemiology of genotypes of hepatitis C virus in Japanese patients with type C chronic liver diseases: A multi-institution analysis |
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| Authors: | EIJI TANAKA KENDO KIYOSAWA TAKASHI MATSUSHIMA KAZUYOSHI ISHIKAWA KUNIHIKO HINO SATOSHI TANAKA HARUHIKO NOSE HIROMITSU KUMADA SHIRO IINO TOMOTERU KAMIMURA MASASHI UNOURA MASASHI MIZOKAMI TAKESHI OKANOUE TETSUO KUROKI GOTARO YAMADA TOHRU MIURA MICHITAMI YANO HIROHITO TSUBOUCHI MICHINORI KOHARA SHUNICHI SATO NOBU HATTORI GNOTYPING ELISA STUDY GROUP |
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| Institution: | Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan;Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan;First Department of Internal Medicine, Iwate Medical University, Morioka, Japan;Second Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan;Liver Unit, The Tokyo Metropolitan Komagome Hospital, Japan;Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan;Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan;Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan;Third Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan;First Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan;Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan;Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan;Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan;First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan;Hepatology Division, Miura Clinic, Kochi, Japan;Institute for Clinical Research, Nagasaki Chuo National Hospital, Nagasaki, Japan;Second Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan;Department of Microbiology, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan |
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| Abstract: | Sixteen medical institutions in Japan collaborated in this study of the epidemiology of hepatitis C virus (HCV) genotypes. A total of 4176 patients with type C chronic liver disease, from the four main islands of Japan, were evaluated. Of those evaluated, 2794 had chronic hepatitis, 727 had liver cirrhosis and 655 had hepatocellular carcinoma. The HCV genotype of the patients was determined by an enzyme-linked immunosorbent assay based on serological genotype 1- and 2-specific recombinant peptides (SG-1 and SG-2, respectively) of the NS4 region. The prevalence of SG-1 and SG-2 HCV was similar in the four main islands of Japan. SG-1 HCV predominated in each disease category (69–76%). The percentage of patients with SG-1 HCV increased by 7%, while that of patients with SG-2 HCV decreased by 7%, as liver disease progressed in severity from chronic hepatitis to carcinoma (P < 0.001). Patients with either SG-1 or SG-2 had a similar mean age and history of blood transfusion. In conclusion, SG-1 HCV was found to predominate in Japan, and the HCV genotype was found to be related to the stage of hepatitis C disease. |
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| Keywords: | chronic liver disease epidemiology genotype hepatitis C virus |
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