| 早期糖尿病大鼠视网膜神经细胞凋亡及胰岛素样生长因子Ⅰ的作用 |
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| 引用本文： | 匡洪宇,邹伟,高昕媛,朱学磊,马丽丽,江红.早期糖尿病大鼠视网膜神经细胞凋亡及胰岛素样生长因子Ⅰ的作用[J].中华内分泌代谢杂志,2006,22(4):382-383. |
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| 作者姓名： | 匡洪宇 邹伟 高昕媛 朱学磊 马丽丽 江红 |
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| 作者单位： | 1. 150001,哈尔滨医科大学第一临床医学院内分泌科
2. 黑龙江中医药大学附属第一医院 |
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| 基金项目： | 黑龙江省科学技术攻关项目（G00C2015） |
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| 摘 要： | 早期糖尿病大鼠被随机分为正常组、糖尿病未治疗组，糖尿病胰岛素治疗组，糖尿病胰岛素样生长因子Ⅰ（ⅠGF—Ⅰ）治疗组，6周后处死大鼠，用原位末端标记法（TUNEL法）标记大鼠视网膜凋亡细胞，免疫组化法观察Bcl-2、Bax蛋白表达。结果表明ⅠGF—Ⅰ可增加Bcl-2表达、减少Bax表达，抑制视网膜神经细胞凋亡。
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| 关 键 词： | 糖尿病视网膜病变 神经元 细胞凋亡 胰岛素样生长因子Ⅰ |
| 收稿时间： | 2005-07-20 |
| 修稿时间： | 2005年7月20日 |
Apoptosis of retinal nerve cells and effects of insulin-like growth factor- Ⅰ in early diabetic rats |
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| KUANG Hong-yu,ZOU Wei,GAO Xin-yuan,ZHU Xue-lei,MA Li-li,JIANG Hong.Apoptosis of retinal nerve cells and effects of insulin-like growth factor- Ⅰ in early diabetic rats[J].Chinese Journal of Endocrinology and Metabolism,2006,22(4):382-383. |
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| Authors: | KUANG Hong-yu ZOU Wei GAO Xin-yuan ZHU Xue-lei MA Li-li JIANG Hong |
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| Institution: | Department of Endocrinology, The First Hospitsl of Harbin Medical Uiversity, Harbin 150001 |
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| Abstract: | Early diabetic rats were randomly divided into normal control group, diabetic control group, diabetic group treated with insulin and diabetic group treated with insulin-like growth factor-I (IGF- I ). All rats were killed after 6 weeks, and the apoptotic retinal nerve cells were stained by the method of TUNEL. Expressions of Bax and Bcl-2 in the retina were studied by immunohistochemistry. IGF- I is able to increase the expression of Bcl-2, decrease the expression of Bax, and restrain the apoptosis in retinal nerve cells. |
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| Keywords: | Diabetic retinopathy Neurons Apoptosis Insulin-like growth factor- I |
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