流产与中国女性乳腺癌发病关系的Meta分析

目的]探讨流产与女性乳腺癌发病之间的关联。方法]利用Meta分析方法对国内1989-2005年公开发表的有关流产与乳腺癌关系的病例对照研究进行定量综合分析。结果]检索出符合纳入标准的6篇病例对照研究文献，共累计病例1440例。对照1785例。6项研究间无一致性（Q值=17．03，P〈0．05）；流产的OR合井（随机效应模型）及其95％CI为2．04（1．50-2．76）。结论]流产与女性乳腺癌发病有关联，有流产史的女性患乳腺癌的风险是无流产史女性的2．04倍。

Meta-analysis of the Relationship between Abortion and Female Breast Cancer in China

Purpose] To investigate the relationship between abortion and breast cancer in Chinese women. Methods] The published case-control studies from 1989 to 2005 about correlation of abortion with breast cancer in China were analyzed using Meta-analysis method to assess the comprehensive relationship between abortion and female breast cancer. Results] Based on the enrolled criteria, 6 articles was searched. The cumulative cases and controls were 1 440 and 1 785 respectively. Significant heterogeneity was detected among the 6 studies (Q=17.03, P<0.05). OR of abortion (random effect model) was 2.04 (95% CI: 1.50~2.76). Conclusions] This meta-analysis suggests a possible association between abortion and female breast cancer. Women with a history of abortion would have 2.04 times risk of being breast cancer than who without history of abortion.