| 真皮下血管网薄皮瓣血管构筑变化与成纤维细胞生长因子的关系 |
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| 引用本文： | 宋业光,修志夫,张智勇,崔彩彬.真皮下血管网薄皮瓣血管构筑变化与成纤维细胞生长因子的关系[J].中华整形外科杂志,1996(5). |
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| 作者姓名： | 宋业光 修志夫 张智勇 崔彩彬 |
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| 作者单位： | 中国医学科学院中国协和医科大学整形外科医院，军事医学科学院二所 |
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| 摘 要： | 为了探讨真皮下血管网薄皮瓣的成活机理，以兔为实验动物，在其背侧形成１５ｃｍ×３ｃｍ的真皮下血管网薄皮瓣，利用微循环显微镜、病理切片、组织化学染色等手段进行观察。结果表明真皮下血管网薄皮瓣术后远、中、近段血管构筑具有明显差别：近段同正常皮肤，中段为极度活跃的血管增生，远段为中度血管增生。皮瓣中段血管构筑的变化起一个“中介蒂”的作用，是皮瓣能够早期断蒂及超过传统长宽比例可以成活的基础。成纤维细胞生长因子是促使皮瓣血管构筑变化的重要因素之一。
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| 关 键 词： | 真皮下血管网 外科 皮瓣血管构筑 成纤维细胞生长因子 |
Experimental study on the effects of FGF on the changes in vascular architecture of subdermal vascular plexus of the thin skin flap |
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| Song Yeguang,Xiu Zhifu,Zhang Zhiyong,et al..Experimental study on the effects of FGF on the changes in vascular architecture of subdermal vascular plexus of the thin skin flap[J].Chinese Journal of Plastic Surgery,1996(5). |
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| Authors: | Song Yeguang Xiu Zhifu Zhang Zhiyong |
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| Institution: | Song Yeguang,Xiu Zhifu,Zhang Zhiyong, et al. |
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| Abstract: | in this experimental study,eight rabbits were used to investigate the survival mechanism of subdermal vascualr plexus thin skin flap. By histological,immunohistochemical and microcirculatory observation,we found that the vascular architecture of different parts of the flap had great dissimilarity:the vascular architecture of the proximal part was same as that of normal skin,the middle one showed extremely active angiogenesis,and the distal part also showed angiogenesis but in medium level. We conclude that the middle part of the flap works as an "intermediary pedicle",and is the basis of the early pedicle division and superior survival ratio of the flap. The fibroblast growth factor(FGF) plays an important role in the changes in vascular architecture of the flap. |
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| Keywords: | Subdermal vascular plexus Skin flap Vascular architecture Fibroblast growth factor (FGF) |
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