| 蛋白酶活化受体4在外周痛觉信号调节作用的研究进展 |
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| 引用本文： | 王昭金,陈丹,张在峰. 蛋白酶活化受体4在外周痛觉信号调节作用的研究进展[J]. 解剖科学进展, 2011, 17(5): 503-505,507 |
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| 作者姓名： | 王昭金 陈丹 张在峰 |
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| 作者单位： | 泰山医学院人体解剖学教研室,山东,泰安,271000 |
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| 基金项目： | 国家自然科学基金资助项目，山东省自然科学基金资助项目 |
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| 摘 要： | 蛋白酶活化受体4(PAR4)是G蛋白偶联受体家族成员之一,可被凝血酶、胰蛋白酶活化。PAR4是血小板活化和炎症的强力调节受体,活化的PAR4可作为潜在的内源性镇痛因子,在正常和炎症条件下参与调节外周疼痛反应。PAR4通过致敏TRPV1、细胞内Ca2+的释放和刺激周围感觉神经末梢释放P物质和CGRP参与了炎症和疼痛的周围机制。PAR4直接与电压门控Ca2+通道的相互作用可能是PAR4对细胞除极诱发的Ca2+信号产生抑制作用和PAR4参与镇痛的作用机制。
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| 关 键 词： | 蛋白酶活化受体 调节作用 镇痛作用 激动剂 凝血酶 炎症 疼痛反应 痛觉过敏 作用机制 家族成员 |
The modulation of PAR4 in nociceptive signaling transduction in primary afferents |
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| WANG Zhao-jin,CHEN Dan,ZHANG Zai-feng. The modulation of PAR4 in nociceptive signaling transduction in primary afferents[J]. Progress of Anatomical Sciences, 2011, 17(5): 503-505,507 |
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| Authors: | WANG Zhao-jin CHEN Dan ZHANG Zai-feng |
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| Affiliation: | WANG Zhao-jin*,CHEN Dan,ZHANG Zai-feng (Department of Anatomy,Taishan Medical University,Shandong Taian 271000 China) |
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| Abstract: | Protease-activated receptor-4 (PAR4), a member of the G protein-coupled receptors family, is activated by thrombin and trypsin. PAR4 is considered as a potent mediator of platelet activation and inflammation, identified as a novel potential endogenous analgesic factor, modulates nociceptive responses in normal and inflammatory conditions. There is clear evidence for the functional involvement of PAR4 in peripheral mechanisms of inflammation and pain, via sensitisation of the transient receptor potential van... |
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