| 氟西汀对野百合碱诱导Wistar大鼠肺动脉和右心室构型重建的影响 |
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| 引用本文： | 王韵,刘明,章新华,王寒明,王丹,张洪艳,白洋,王怀良. 氟西汀对野百合碱诱导Wistar大鼠肺动脉和右心室构型重建的影响[J]. 解剖科学进展, 2011, 17(5): 428-431 |
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| 作者姓名： | 王韵 刘明 章新华 王寒明 王丹 张洪艳 白洋 王怀良 |
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| 作者单位： | 1. 中国医科大学临床药理教研室,辽宁,沈阳,110001
2. 中国刑警学院禁毒系,辽宁,沈阳,110035 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的 研究氟西汀对野百合碱(monocrotaline,MCT)诱导Wistar大鼠肺动脉和右心室构型重建的影响.方法 应用野百合碱建立大鼠肺动脉高压模型,40只Wistar大鼠均分为4组:对照组(control)、模型组(MCT)、氟西汀低剂量2mg/kg组(MCT+F2)和氟西汀高剂量lOmg/kg组(MCT+F1...
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| 关 键 词： | 氟西汀 肺动脉高压 野百合碱 肺血管重构 右心肥厚 Wistar大鼠 |
Effect of fluoxetine on monocrotaline-induced remodeling of pulmonary arteries and right ventricle in rats |
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| WANG Yun,LIU Ming,ZHANG Xin-hua,WANG Han-ming,WANG Dan,ZHANG Hong-yan,BAI Yang,WANG Huai-liang. Effect of fluoxetine on monocrotaline-induced remodeling of pulmonary arteries and right ventricle in rats[J]. Progress of Anatomical Sciences, 2011, 17(5): 428-431 |
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| Authors: | WANG Yun LIU Ming ZHANG Xin-hua WANG Han-ming WANG Dan ZHANG Hong-yan BAI Yang WANG Huai-liang |
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| Affiliation: | WANG Yun1,LIU Ming2,ZHANG Xin-hua1,WANG Han-ming1,WANG Dan1,ZHANG Hong-yan1,BAI Yang1,WANG Huai-liang1* (1. Department of Clinical Pharmacology,China Medical University,Shenyang 110001,2. Department of Drug Control,China Criminal Police University,Shenyang 110035 China) |
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| Abstract: | Objective To investigate the effect of fluoxetine on monocrotaline (MCT)-induced remodeling of the pulmonary arteries and the right ventricle in rats. Methods Models of pulmonary arterial hypertension (PAH) were established by MCT. 40 Wistar rats were divided into four groups: control group, model group (MCT), treatment group with fluoxetine at 2mg/kg (MCT+F2) and at 10mg/kg (MCT+F10) respectively. Pulmonary arterial pressure and systemic arterial pressure were recorded by the polygraph system. The lung and... |
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| Keywords: | fluoxetine pulmonary arterial hypertension monocrotaline pulmonary vascular remodeling right ventricular hypertrophy Wistar rat |
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