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| 硫酸软骨素酶ABC在中枢神经系统中促进神经再生的作用 | |
| 引用本文： | 王莹,贾桦,李文媛,佟晓杰.硫酸软骨素酶ABC在中枢神经系统中促进神经再生的作用[J].解剖科学进展,2011,17(5):484-486. |
| 作者姓名： | 王莹 贾桦 李文媛 佟晓杰 |
| 作者单位： | 1. 牡丹江医学院解剖教研室,黑龙江,牡丹江,157011;中国医科大学解剖学教研室,辽宁,沈阳,110001 2. 中国医科大学解剖学教研室,辽宁,沈阳,110001 3. 牡丹江医学院解剖教研室,黑龙江,牡丹江,157011 |
| 基金项目： | 高等学校博士学科点专项基金 |
| 摘 要： | 中枢神经系统(CNS)损伤后因胶质瘢痕形成而导致神经元的轴突不能再生,功能恢复不良.胶质瘢痕的重要组分是硫酸软骨素蛋白聚糖(CSPGs),其单独或与其它细胞外基质结合,导致向损伤部位延伸的轴突在胶质瘢痕处停止,而且CSPGs在神经再生时间窗关键期末可降低轴突生长的可塑性.近年研究发现硫酸软骨素酶ABC(chondroi... |
| 关 键 词： | 中枢神经系统损伤 轴突生长 神经再生 胶质瘢痕 可塑性 硫酸软骨素酶 损伤部位 运动功能恢复 细胞外基质 轴突再生 |
The Role of chondroitinase ABC in promoting neural regeneration and plasticity in central nervous system |
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| WANG Ying,JIA Hua,LI Wen-yuan,TONG Xiao-jie.The Role of chondroitinase ABC in promoting neural regeneration and plasticity in central nervous system[J].Progress of Anatomical Sciences,2011,17(5):484-486. | |
| Authors: | WANG Ying JIA Hua LI Wen-yuan TONG Xiao-jie |
| Institution: | WANG Ying1,2,JIA Hua2,LI Wen-yuan1,TONG Xiao-jie2* (1.Department of Anatomy,Mudanjiang Medical College,Mudanjiang 157011,2. Department of Anatomy,China Medical University,Liaoning Shenyang 110001 China) |
| Abstract: | Following the mammalian central nervous system (CNS) injuries, it is very difficult for the axons of the neurons to regenerate and recover due to the restricted neural plasticity by the glial scar. Axon regeneration is inhibited by the presence of various inhibitory molecules, including chondroitin sulfate proteoglycans (CSPGs). Plasticity after the end of critical period is also restricted by CSPG. Chondroitinase ABC promotes axonal regeneration and reactivates the axonal plasticity. This review summarizes... |
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