| 高效液相色谱法测定金泽冠心胶囊中泽泻醇B-23-乙酸酯含量 |
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| 引用本文： | 谢香菊,王贤英,赵建权,李胜容.高效液相色谱法测定金泽冠心胶囊中泽泻醇B-23-乙酸酯含量[J].中国药业,2010,19(16):35-36. |
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| 作者姓名： | 谢香菊 王贤英 赵建权 李胜容 |
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| 作者单位： | 重庆市中药研究院,重庆,400065 |
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| 摘 要： | 目的应用高效液相色谱法测定金泽冠心胶囊中泽泻醇B-23-乙酸酯的含量。方法采用Diamonsil^TM（钻石）C18色谱柱（250mm×4.6mm,5μm）,流动相为乙腈-水（70∶30）,流速为1.0mL/min,检测波长为208nm。结果泽泻醇B-23-乙酸酯进样量在0.7312～2.9248μg范围内与峰面积线性关系良好（r=0.9999）,平均加样回收率为99.15%,RSD为0.96%（n=6）。结论该法操作简便、准确,灵敏度高,重现性好,可用于金泽冠心胶囊中泽泻醇B-23-乙酸酯的含量测定。
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| 关 键 词： | 高效液相色谱法 金泽冠心胶囊 泽泻醇B-23-乙酸酯 含量测定 |
Determination of Alisol B-23-Acetate in Jinze Guanxin Capsules by HPLC |
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| Xie Xiangju,Wang Xianying,Zhao Jianquan,Li Shengrong.Determination of Alisol B-23-Acetate in Jinze Guanxin Capsules by HPLC[J].China Pharmaceuticals,2010,19(16):35-36. |
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| Authors: | Xie Xiangju Wang Xianying Zhao Jianquan Li Shengrong |
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| Institution: | ( Chongqing Academy of Chinese Traditional Medicine, Chongqing, China 400065) |
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| Abstract: | Objective To establish a HPLC method for the determination of alisol B-23-acetate in Jinze Guanxin Capsules. Methods The stationary phase was Diamonsil^TM C18 column（250 mm × 4. 6 mm,5 μm）,the mobile phase was acetonitrile-water（70 ∶ 30）,the flow rate was 1. 0 mL /min,the UV detection wavelength was 208 nm. Results The alisol B-23-acetate was linear within the range of 0. 731 2-2. 924 8 μg （ r = 0. 999 9）,and the average recovery rate was 99. 15% with RSD was 0. 96% （ n = 6） . Conclusion The method is simple,accurate,highly sensitive and reproducible,which can be used for the quantitative determination of alisol B-23-acetate in Jinze Guanxin Capsules. |
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| Keywords: | HPLC Jinze Guanxin Capsules alisol B - 23 - acetate content determination |
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