中青年肥胖对高血压亚型患病率和同型半胱氨酸水平影响的研究

目的探讨中青年超重和肥胖对高血压各亚型患病率的影响。方法选取2012年9月在我院进行体检的某单位职工为研究对象,分析其中具有完整身高、体重、血压测量资料和生化指标且未服用降压药物的共计300名研究对象的结果。比较中青年超重和肥胖对高血压各亚型患病率和血清同型半胱氨酸（Hcy）水平的影响。结果该单位员工的超重和肥胖率分别达到35%和10.33%,男性更高,30~49岁间是超重和肥胖的患病高峰。随着BMI水平增加,男性和女性的收缩压、舒张压均值和血Hcy水平逐渐升高,在超重和肥胖组中,血压的性别差异消失。肥胖组血Hcy的性别差异消失。该单位员工总体高血压患病率为16%,在超重和肥胖组中分别达到20%和45.16%,收缩期和舒张期联合高血压（SDH）和单纯舒张期高血压（IDH）患病率高于单纯收缩期高血压（ISH）。30~49岁的中青年人群高血压亚型以SDH和IDH为主。2/3以上的超重或肥胖合并SDH或IDH是分布在中青年人群。37.5%和42.85%的30~49岁肥胖者合并高Hcy血症。结论超重和肥胖人群中血压和同型半胱氨酸的性别差异消失,高血压亚型以SDH和IDH为主,大多数的超重或肥胖合并SDH或IDH发生在30~49岁的中青年,应重点针对这部分人群开展综合健康促进措施防治高血压和高同型半胱氨酸血症。

The association of young and middle-aged obesity and hypertension subtypes and serum homocysteine

Objective To explore the effect of the young and middle-aged overweight and obesity on the prevalence of hypertension subtype.Methods We selected 300 subjects who had medical examination and without taking antihypertensive drugs in our hospital in Sep 2012,and analysed complete data containing height,weight,blood pressure measurements and biochemical parameters.Compared the effect of young and middleaged overweight and obesity on the prevalence of hypertension subtypes and serum homocysteine（Hcy） levels.Results The overweight rate and obesity rate were 35% and 10.33%,respectively,and the male is higher.The peak prevalence of overweight and obesity in the age of 30 to 49.Male and female systolic blood pressure,diastolic blood pressure and mean blood Hcy levels were gradually increased with the increasing of BMI levels.In overweight and obesity group,gender differences disappeared in blood pressure.In obesity group,Hcy levels had no difference in different gender.The total hypertension prevalence rate was 16%,and the overweight and obese group reached 20% and 45.16%,respectively.The prevalence rate systolic and diastolic hypertension（SDH） and isolated diastolic hypertension（IDH） higher than that of isolated systolic hypertension（ISH）.SDH and IDH were the main hypertension subtypes in the age of 30 to 49 populations.2/3 of the overweight or obese combined SDH or IDH were distributed in young and middle-aged crowd.There were 37.5% and 42.85% obese subjects had hyperhomocysteinemia in the age of 30~49.Conclusion There was no sexual difference of blood pressure and serum homocysteine in overweight and obesity group.The main hypertension subtypes were SDH and IDH.The majority of overweight or obesity subjects combined with SDH or IDH were distributed in 30~49 years old.These people should be intensively offered healthy promotion measurements to prevent hypertension and hyperhomocysteinemia..