| 培哚普利对心肌缺血再灌注损伤早期Toll样受体4表达的影响 |
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| 引用本文： | 郭文超,牛凡,路映攀.培哚普利对心肌缺血再灌注损伤早期Toll样受体4表达的影响[J].中西医结合心脑血管病杂志,2010,8(2):194-195. |
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| 作者姓名： | 郭文超 牛凡 路映攀 |
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| 作者单位： | 山西医科大学第一临床医学院,030001 |
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| 摘 要： | 目的观察培哚普利对缺血再灌注早期Toll样受体4蛋白（TLR4）的影响，初步探讨其对心肌缺血再灌注损伤的保护机制。方法30只Wistar大鼠随机分为假手术组、缺血再灌注组及培哚普利组。培哚普利组灌服培哚普利4mg／kg，每日1次，共7d。结扎大鼠左冠状动脉前降支（LAD），建立大鼠缺血再灌注模型，光镜观察心肌形态学改变，TUNEI，法检测细胞凋亡数及免疫组化检测心肌组织中TLR4表达情况。结果与缺血再灌注组相比，培哚普利组炎症损伤减轻；培哚普利组心肌细胞凋亡数明显低于缺血再灌注组，但高于假手术组（P〈0．05）；培哚普利组心肌组织TLR4表达低于缺血再灌注组，但高于假手术组（P〈0．05）。结论培哚普利可减轻心肌缺血再灌注早期的细胞凋亡，其机制之一可能是通过抑制TLR4所介导的炎症反应实现的。
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| 关 键 词： | 培哚普利 心肌缺血再灌注 细胞凋亡 Toll样受体4蛋白 |
Influence of Perindopril on Expression of Toll-like Receptor-4 in Rats with Early Ischemia-reperfusion Injury |
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| Guo Wenchao,Niu Fan,Lu Yingpan.Influence of Perindopril on Expression of Toll-like Receptor-4 in Rats with Early Ischemia-reperfusion Injury[J].Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease,2010,8(2):194-195. |
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| Authors: | Guo Wenchao Niu Fan Lu Yingpan |
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| Institution: | Guo Wenchao,Niu Fan,Lu Yingpan The First Clinical Medical College,Shanxi Medical University (Taiyuan 030001) |
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| Abstract: | Objective To investigate the influence of perindopril on expression of toll-like receptor-4 (TLR-4) in rats with early myocardial ischemia-reperfusion (IR) injury and explore the possible mechanisms of perindopril in inhibition of myocardial ischemia-reperfusion injury.Methods Thirty Wistar rats were randomly divided into 3 groups:Sham operation group,myocardial IR group and perindopril group treated with perindopril.The left anterior descending artery in Wistar rats was ligated to establish IR model.Morpho... |
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| Keywords: | perindopril myocardial ischemia-reperfusion injury apoptosis toll-like receptor-4 |
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