前列环素信号通路的研究进展

前列环素（PGI2）是前列腺素家族的重要成员,由花生四烯酸在血管内皮细胞环氧合酶和前列环素合酶的作用下生成。PGI2与细胞膜上组织特异性的G蛋白偶联受体前列环素受体相结合,激活腺苷酸环化酶,增加cAMP的含量,激活蛋白激酶A,从而发挥舒张血管、抑制血小板聚集、抑制血管平滑肌细胞增殖和迁移等作用。高浓度时,PGI2可与一种核受体过氧化物酶体增殖物激活受体相互作用,调节心血管系统多种生理功能,如血管新生等。本文就PGI2合成和信号转导通路的研究进展进行综述。

Prostacyclin signal pathway：research advances

Prostacyclin（PGI2） is a member of the prostaglandins family and the main product of arachidonic acid metabolism by cyclooxygenase and prostaglandin synthase.PGI2 mediates cellular activity through binding to G-protein coupled receptor,prostacyclin receptor,therefore leading to activation of adenylyl cyclase,accumulation of cAMP and activation of PKA.PGI2 plays an important role in vascular biology such as regulating vasodilation,platelet aggregation,vascular permeability,and vascular smooth muscle cell proliferation.At high concentrations,PGI2 is able to interact with peroxisomal proliferator-activated receptor,a class of nuclear receptors,and modulatespecific cellular functions suchas angiogenesis.This paper reviews the research advances in PGI2 synthesis and signal pathway.