胍丁胺抗阿片依赖研究进展

阿片成瘾,又称为阿片依赖,是一种慢性复发性脑疾病,可引起一系列严重的社会、经济和公共卫生问题。由于阿片依赖的神经生物学机制尚未阐明,目前仍缺乏有效的医学干预手段。研究阿片依赖的神经生物学机制、寻找有效的防复吸药物已成为阿片依赖研究领域的热点。胍丁胺是一种新发现的候选神经递质或调质,被认为是咪唑啉受体的内源性配体,本文主要以我们的研究工作为基础,对外源性胍丁胺的抗阿片依赖作用特点及其可能的作用机制加以综述。

Progress in agmatine inhibiting opioid dependence

Opioid addiction,also termed opioid dependence,is a chronic, relapsing disorder in brain,which induces a series of severe problems in the aspects of society,economy and public health. Because the neurobiological mechanisms of opioid dependence haven′t been clarified,it lacks effective medical interventions. Researches on opioid dependence are focusing on clarifying its neurobiological mechanisms and discovering effective anti-relapse drugs. Agmatine is a candidate for neurotransmitter or neuromodulator,and considered as an endogenous ligand for imidazoline receptors. Based on our previous work,its pharmacological characteristics and possible mechanisms of agmatine inhibiting opioid dependence were reviewed.