微球在组织工程中的应用

组织工程一直是生命科学领域研究的热点,存在着不少亟待解决的难题,如种子细胞的扩增、工程支架的制备、组织工程所需药物的控制释放等。在解决这些难题时,常要用到微球技术,如微球可以用作微载体培养种子细胞、也可用于制备支架或直接用作支架、还可作为控制药物释放的载体。本文主要介绍微球在组织工程中的应用概况,并总结有关微载体性能改良、微球制成支架,以及载药微球加入支架技术方法的研究进展。

Applications of microspheres in tissue engineering

Tissue engineering has always been a hot spot in the life science area over the past few years.However,there are some problems,such as the multiplication of seeding cells,the preparation of tissue engineering scaffolds,and the controlled release of drugs from scaffolds and so on.Recently microspheres have been widely used to solve these problems.For example,microspheres are used as microcarriers to culture seeding cells.In addition,microsphers can be either used to prepare engineering scaffolds or directly used as scaffolds.Microspheres can be used to load drugs and control the drug release as well.In this paper the application of microspheres in tissue engineering is reviewed and the up-to-date methods are introduced,including ways of improving performances of microcarriers,preparing scaffolds with microspheres and adding drug-loaded microspheres into scaffolds.