| 自组装药物传递系统 |
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| 引用本文： | 金义光.自组装药物传递系统[J].国外医学(药学分册),2010(3):165-169,186. |
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| 作者姓名： | 金义光 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所七室,北京100850 |
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| 基金项目： | 国家“重大新药创制”科技重大专项——综合性新药研究开发技术大平台资助项目（2009ZX09301-002） |
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| 摘 要： | 自组装药物传递系统（SADDS）是基于药质体提出的新概念和新给药系统,融合了前药、分子自组装和纳米技术,是两亲前药形成的自组装纳米体系。其突出的特点是自组装体几乎没有辅料的参与,载药量大,稳定性好,在体内可获得靶向、控释效果,特别适合于抗病毒和抗肿瘤治疗。SADDS是学科交叉的产物,是药剂学研究的新方向。本文阐述了SADDS概念的来源、特点和研究进展,并展望了SADDS的研究前景。
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| 关 键 词： | 前药 自组装 纳米技术 自组装药物传递系统 药质体 靶向制剂 |
Self-assembled drug delivery system |
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| JIN Yi-guang.Self-assembled drug delivery system[J].Foreign Medical Sciences(Section of Pharmarcy),2010(3):165-169,186. |
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| Authors: | JIN Yi-guang |
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| Institution: | JIN Yi-guang(Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | Self-assembled drug delivery system（SADDS） is a novel concept and a novel drug delivery system based on pharmacosomes. It integrates prodrug,molecular self-assembly and nanotechnology and can be defined as the nanosized self-assembled system formed from amphiphilic prodrugs. Its outstanding advantages include：a） the self-assemblies composed of prodrugs without excipients; b） high drug loads; c） strong stability; and d） in vivo targeting and controlled release. It can be applied to antiviral and anticancer therapy. SADDS is an inter-disciplinary product representing the latest progress in pharmaceutics. This paper describes the concept resource,characteristics and research progress in SADDS and analyzes the prospective of SADDS. |
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| Keywords: | prodrug self-assembly nanotechnology self-assembled drug delivery systems pharmacosomes targeted drug delivery systems |
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