| 补体C5a、C5a受体及其拮抗剂的研究进展 |
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| 引用本文： | 王会会,陈国江,黎燕,石艳春.补体C5a、C5a受体及其拮抗剂的研究进展[J].国外医学(药学分册),2010(3):181-186. |
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| 作者姓名： | 王会会 陈国江 黎燕 石艳春 |
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| 作者单位： | [1]内蒙古医学院分子生物学中心,呼和浩特010059 [2]军事医学科学院基础医学研究所分子免疫学研究室,北京100850 |
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| 基金项目： | 国家自然科学基金项目（30801029）; 国家重点基础研究发展计划资助项目（2007CB512406） |
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| 摘 要： | C5a是最重要的补体活化产物之一,它与相应的C5a受体结合被激活后,参与了多种疾病的病理过程,如急性肺损伤、脓毒血症、类风湿性关节炎、肾小球肾炎等疾病。如何阻断C5a信号的下传,从而减轻炎症反应一直是免疫学研究的热点问题。目前C5a和C5a受体的拮抗剂主要分为抗C5a抗体、小分子拮抗剂、C5a反义肽、C5a突变体和细菌来源的趋化抑制蛋白等。本文着重介绍C5a和C5a受体的结构与功能,以及相关拮抗剂的研究进展。
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| 关 键 词： | 补体C5a C5a受体 C5a拮抗剂 C5a受体拮抗剂 |
Complement C5a,C5a receptor and their antagonists：research advances |
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| WANG Hui-hui,CHEN Guo-jiang,LI Yan,SHI Yan-chun.Complement C5a,C5a receptor and their antagonists：research advances[J].Foreign Medical Sciences(Section of Pharmarcy),2010(3):181-186. |
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| Authors: | WANG Hui-hui CHEN Guo-jiang LI Yan SHI Yan-chun |
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| Institution: | 1.Research Center for Molecular Biology,Inner Mongolia Medical College,Hohhot 010059,China; 2.Department of Molecular Immunology,Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | As one of the most important products of complement activation,C5a,after binding to its receptors （C5aR）,has been considered to be involved in the pathology of numerous inflammatory diseases,such as acute lung injury,sepsis,rheumatoid arthritis and glomerular nephritis. Therefore,the focus of current studies on how to block C5a and C5aR signal transduction for dampening the inflammatory reaction. Recently,several antagonists of C5a and C5aR were reported,including C5a antibody,small molecule human C5aR antagonists,C5a antisense peptide,C5a mutant and the complex of chemotaxis inhibitory protein of Staphylococcus aureus with C5aR. In this review,the structure and function of C5a and C5aR,and the advances in the research on their antagonists are summarized. |
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| Keywords: | complement C5a C5a receptor C5a antagonist C5a receptor antagonist |
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