| 幽门螺杆菌感染患者血清尿素酶B亚单位测定及意义 |
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| 引用本文： | 陈国弟,李倩,朱永良,吴勤动. 幽门螺杆菌感染患者血清尿素酶B亚单位测定及意义[J]. 浙江预防医学, 2004, 16(9): 11-12 |
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| 作者姓名： | 陈国弟 李倩 朱永良 吴勤动 |
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| 作者单位： | 1. 浙江大学医学院附属第二医院,浙江,杭州,310009
2. 浙江大学医学院附属儿童医院 |
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| 摘 要： | 目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)尿素酶B亚单位(Urease sulbunit B,UreB)核心多肽作为疫苗抗原的可能性.方法应用酶免疫法测定H.pylori感染患者血清游离Ure B及各型免疫复合物.结果61例H.pylori感染患者血清中,游离Ure B及Ure B-IgG、Ure B-IgA、Ure B-IgM任一项阳性者60例,占98.4%,其中游离Ure B阳性率63.9%,UreB-IgG为62.3%,Ure B-IgA为75.4%,UreR-IgM为78.7%.结论H.pylori感染患者血清中存在Ure B,Ure B核心多肽能引起特异性免疫应答,Ure B核心多肽可望成为疫苗抗原.
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| 关 键 词： | 幽门螺杆菌 尿素酶B亚单位 核心多肽 疫苗 抗原 |
| 文章编号： | 1007-0931(2004)09-0011-02 |
| 修稿时间： | 2004-02-17 |
Detecting of Urease Subunit B in Serum from Patients with Helicobacter Pylori Infection |
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| CHEN Guodi,LI Qian,Zhu yongliang,et al.. Detecting of Urease Subunit B in Serum from Patients with Helicobacter Pylori Infection[J]. Zhejiang Journal of Preventive Medicine, 2004, 16(9): 11-12 |
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| Authors: | CHEN Guodi LI Qian Zhu yongliang et al. |
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| Abstract: | Objective To analyze possibility of Ure B core polypeptide acting as vaccine antigen protecting from H.pylori infection.Methods Free Ure B and its immune complex in serum were detected from Patients with Helicobacter Pylori infection.Results in 61 Patients with Helicobacter Pylori infection,the positive rate of free Ure B is 63.9%,Ure B-IgG 62.3%,Ure B-IgA 75.5%,Ure B_IgM 78.7%.There are 60 patients with any one posiotive of four detections,the positive rate is 98.4%.Conclusions There exists H.Pylori Ure B in serum from patients with H.pylori infection.H.pylori Ure B core polypeptide can invoke specific immune response,It is more possible that Ure B core polyeptide act as vaccine antigen protecting from H.pylori infection. |
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| Keywords: | Helicobacter pylori Urease subunit B Core polypeptide Vaccine Antigen |
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