| 重组人酸性成纤维细胞生长因子的生殖毒性 |
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| 引用本文： | 姚成灿, 许华, 郑青, 赵文, 吴晓萍, 黄亚东, 李校堃. 重组人酸性成纤维细胞生长因子的生殖毒性[J]. 中国药科大学学报, 2005, 36(5): 461-463. |
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| 作者姓名： | 姚成灿 许华 郑青 赵文 吴晓萍 黄亚东 李校堃 |
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| 作者单位： | 暨南大学药学院,广州,510632 |
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| 基金项目： | 国家高技术研究发展计划(863计划)，广东省广州市科技攻关项目 |
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| 摘 要： | 目的:研究重组人酸性成纤维细胞生长因子(rhaFGF)在破损皮肤表面给药时的生殖毒性。方法:从SD大鼠怀孕第6天起对破损皮肤连续给药10 d,剂量分别为3 600 U/cm2,1 800 U/cm2,900 U/cm2,观察rhaFGF对大鼠的生育能力、胎鼠的生长发育及骨骼发育的影响。结果:大鼠破损皮肤外用相当于有效剂量603、0和15倍的rhaFGF对母体的毒性、胚胎毒性和致畸作用均无明显的影响。结论:在相当于有效剂量60倍的剂量下使用rhaFGF对母体和胎儿是安全的。
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| 关 键 词： | 重组人酸性成纤维细胞生长因子 生殖毒性 皮肤用药 |
| 文章编号： | 1000-5048(2005)05-0461-03 |
| 收稿时间： | 2005-02-09 |
| 修稿时间： | 2005-02-09 |
Toxicity of Recombinant Human Acidic Fibroblast Growth Factor on Reproduction System |
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| YAO Cheng-Can,XU Hu,ZHENG Qing,ZHAO Wen,WU Xiao-Ping,HUANG Ya-Dong,LI Xiao-Kun. Toxicity of Recombinant Human Acidic Fibroblast Growth Factor on Reproduction System[J]. Journal of China Pharmaceutical University, 2005, 36(5): 461-463 |
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| Authors: | YAO Cheng-Can XU Hu ZHENG Qing ZHAO Wen WU Xiao-Ping HUANG Ya-Dong LI Xiao-Kun |
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| Abstract: | AIM:To investigate the toxicity of recombinant human acidic fibroblast growth factor(rhaFGF) on reproduction system in rats.METHODS:The damaged skin on rats was treated with rhaFGF at the dose of(3 600 U/cm~(2)),1 800 U/cm~(2) and 900 U/cm~(2) respectively,once a day for 10 days successively.The fertile activity of mother rats and growing development of embryo was observed.RESULTS:No significant differences in the toxicity of mother rats,or embryo teratogenesis were found between each of group even when treated with rhaFGF at 60-fold effective doses.CONCLUSION: The safety on pregnant rats and the fetus upon treatment on topical damage skin with rhaFGF of doses up to 60-fold effective dose was confirmed. |
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| Keywords: | Recombinant human acidic fibroblast growth factor Toxicity on reproduction system Transdermal |
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