| 原发性肝癌中GSTM1基因多态与P53249密码子突变的相关研究 |
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| 引用本文： | 胡应 沈福民. 原发性肝癌中GSTM1基因多态与P53249密码子突变的相关研究[J]. 中华医学遗传学杂志, 1997, 14(2): 76-78 |
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| 作者姓名： | 胡应 沈福民 |
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| 作者单位： | 上海医科大学流行病学教研室 |
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| 基金项目： | 国家自然科学基金 中国博士后科学基金 |
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| 摘 要： | 为了探索肝癌的发生是否同人体解毒酶系统中某些解毒酶如ＧＳＴ的功能缺陷有关，我们检测了１４７个正常个体和４５例原发性肝癌组织Ｐ５３基因２４９密码子突变情况，结果发现ＧＳＴＭ２－ｍｕｌｌ等位基因在正常人群中的频率为０．７１，而在患者中为０．８２，经统计检验其差异有显著性。在３７个原发性肝癌患者中，发现２４９密码子突变８例，且均为ＧＳＴＭＩ－ｎｕｌｌ纯合子。表明ＧＳＴＭ１在肝癌的演化和发生中，经解毒黄曲
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| 关 键 词： | 肝肿瘤 GSTM1 P53基因 |
ASSOCIATION BETWEEN GSTM1 GENE POLYMORPHISM OF PRIMARY HEPATOCELLULAR CARCINOMA AND MUTATION OF p53 CODON 249 |
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| Hu Ying,Shen Fumin. ASSOCIATION BETWEEN GSTM1 GENE POLYMORPHISM OF PRIMARY HEPATOCELLULAR CARCINOMA AND MUTATION OF p53 CODON 249[J]. Chinese journal of medical genetics, 1997, 14(2): 76-78 |
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| Authors: | Hu Ying Shen Fumin |
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| Affiliation: | Hu Ying,Shen Fumin. Department of Epidemiology,Shanghai Medical University,Shanghai 200032 |
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| Abstract: | The GSTM1 gene polymorphism of both the peripheral white cells of 147 normal subjects and the normal liver tissue of 45 patients with primary hepatocellular carcinoma(PHC), and the mutation of p53 codon 249 of liver cancer tissue of 37 patients with PHC were detected. It was found that the allele frequency of GSTM1 null type among general population was 0.71, while that among PHC patients was 0.82. The difference between the two allele frequncies was statistically significant. Of the 37 PHC patients detected, 8 were found positive in codon mutation; in addition, all of these 8 cases were homozygotes of GSTM1 null type. |
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| Keywords: | Primary hepatiocellular carcinoma GSTM1 gene p53 gene |
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