| 急性髓细胞白血病H—ras基因点突变及临床相关性研究 |
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| 引用本文： | 李栋梁 宣宝和. 急性髓细胞白血病H—ras基因点突变及临床相关性研究[J]. 中华医学遗传学杂志, 1997, 14(2): 82-84 |
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| 作者姓名： | 李栋梁 宣宝和 |
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| 作者单位： | 解放军白求恩国际和平医院血液内科，解放军第二六零医院内科，河北医科大学分子生物学研究中心 |
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| 摘 要： | 为了解急性髓细胞白血病（ＡＭＬ）Ｈ－ｒａｓ基因点突变的情况，应用聚合酶链反应和限制性酶切图谱分析技术，对５５例初诊ＡＭＬ患者进行了检测，发现１６例（２９．１％）存在Ｈ－ｒａｓ基因点突变，此突变与ＡＭＬ的发生及某些临床指标有一定关系。Ｈ－ｒａｓ基因突变可望成为ＡＭＬ诊断分型、指导治疗及判断预后的一项有价值的指标。
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| 关 键 词： | ras基因 突变 聚合酶链反应 白血病，髓细胞性 |
POINT MUTATION OF H ras GENE AND ITS CLINICAL INTERELATION IN ACUTE MYELOID LEUKEMIA |
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| Li Dongliang,Xuan Baohe,Wen Jinkun,et al.. POINT MUTATION OF H ras GENE AND ITS CLINICAL INTERELATION IN ACUTE MYELOID LEUKEMIA[J]. Chinese journal of medical genetics, 1997, 14(2): 82-84 |
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| Authors: | Li Dongliang Xuan Baohe Wen Jinkun et al. |
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| Affiliation: | Li Dongliang,Xuan Baohe,Wen Jinkun,et al.The Bethune International Peace Hospital,Shijiazhang 050082 |
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| Abstract: | To inquire into the situation of H ras gene point mutation in acute myeloid leukemia(AML),55 cases of AML were detected.The result showed that 16 cases(29.1%) contained H ras gene point mutation,and the mutation had certain correlation with leukemogenesis and some clinical parameters of AML.H ras gene mutation may probably be used as valuable predictor in typing diagnosis,directing treatment and determing outcome of AML. |
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| Keywords: | ras gene Mutation Polymerase chain reaction Acute myeloid leukemia |
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