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An estimate of the minimal frequency of cytolytic T lymphocyte effector cells generated in allogeneic reactions. |
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| Authors: | H D Engers F W Fitch |
| Institution: | 1. Department of Immunology, Swiss Institute for Experimental Cancer Research, 1066 Epalinges s/Lausanne, Switzerland;2. Department of Pathology and the Franklin McLean Memorial Research Institute, University of Chicago, Chicago, IL. 60637, U.S.A. |
| Abstract: | A 'micro' modification of the standard 51Cr release assay was developed. With this assay, significant cytolysis was obtained employing 100--200 51Cr-labeled target cells and fewer than 100 lymphocytes obtained from mixed leukocyte cultures. A minimal estimate as to the actual frequency of effector cells was determined for both primary (1 cell in 30) and secondary (1 cells in 8) cytolytic T lymphocyte populations. |
| Keywords: | Correspondence: H D Engers Dept of Immunology ISREC CH 1066 Epalinges s/Lausanne Switzerland |
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